The excessive conversion charge of curcumin prodrug TBP1901 to curcumin in bone marrow warrants its medical software for ailments rising within the marrow like a number of myeloma and leukemia. The pure polyphenol curcumin has proven promising efficacy with tumors in plenty of preclinical fashions. Credit score: KyotoU / World Comms
Prodrug curcumin shows medical potential.
In most cancers medical research, curcumin, a pure molecule associated to turmeric, has been used to deal with most cancers sufferers. Regardless of its identified antitumor results, drug improvement has lagged attributable to challenges involving its chemistry.
Now, a group of researchers at Kyoto College has developed a prodrug type of curcumin, TBP1901, that has proven anti-tumor results with out toxicities.
“Curcumin has lengthy been used as a spice or meals coloring, so we count on to see minimal uncomfortable side effects,” says lead writer Masashi Kanai.
Curcumin, a pure polyphenol, has demonstrated promising efficacy in opposition to tumors in a number of preclinical fashions. Such research have reported anecdotal proof of curcumin’s impact in most cancers sufferers.
Nevertheless, curcumin’s restricted bioavailability and low stability have hampered its medical software so far.
Kanai’s group has discovered a attainable detour round the issue by deductively figuring out the enzyme GUSB for its key function in TBP1901 conversion to curcumin. The scientists hypothesized that this conversion wouldn’t be noticed in mice with genetically impaired GUSB. Additionally they confirmed, utilizing a CRISPR-Cas9 display technique, that curcumin additionally has important therapeutic targets.
“The excessive conversion charge of TBP1901 to curcumin in bone marrow warrants its medical software for ailments rising within the marrow like a number of myeloma and leukemia,” notes Kanai.
Reference: “Pharmacologic characterization of TBP1901, a prodrug type of aglycone curcumin, and CRISPR-Cas9 display for therapeutic targets of aglycone curcumin” by Tomoyuki Abe, Yoshihito Horisawa, Osamu Kikuchi, Hitomi Ozawa-Umeta, Atsuhiro Kishimoto, Yasuhiro Katsuura, Atsushi Imaizumi, Tadashi Hashimoto, Kotaro Shirakawa, Akifumi Takaori-Kondo, Kosuke Yusa, Tadashi Asakura, Hideaki Kakeya, and Masashi Kanai, 10 October 2022, European Journal of Pharmacology.
DOI: 10.1016/j.ejphar.2022.175321
The examine was funded by the Japan Society for the Promotion of Science.
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